Characterization of Three Novel Adhesins of Leptospira interrogans
نویسندگان
چکیده
منابع مشابه
Identification of Cell-Binding Adhesins of Leptospira interrogans
Leptospirosis is a globally distributed bacterial infectious disease caused by pathogenic members of the genus Leptospira. Infection can lead to illness ranging from mild and non-specific to severe, with jaundice, kidney and liver dysfunction, and widespread endothelial damage. The adhesion of pathogenic Leptospira species (spp.), the causative agent of leptospirosis, to host tissue components ...
متن کاملIdentification and Characterization of Novel Adhesins in Leptospira
Leptospirosis is a worldwide zoonosis of human and veterinary concern, caused by pathogenic spirochetes of the genus Leptospira. This work reviews the ability of six putative leptospiral outer membrane proteins to interact with extracellular matrix (ECM) molecules. The chosen the genes, LIC10314, LIC10368, LIC12099, LIC12895, LIC12906 and LIC12690, were selected from the genome sequences of L. ...
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Leptospirosis caused by infection with pathogenic leptospires, which is the most prevalent zoonotic disease in the world. The outer membrane proteins (OMPs) of pathogenic leptospires such as LipL41 play a crucial role in pathogenesis of this disease. Therefore a major challenge to develop an effective vaccine against leptospirosis is application of basic research on the OMPs of leptospires to i...
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We report in this work that Leptospira strains, virulent L. interrogans serovar Copenhageni, attenuated L. interrogans serovar Copenhageni and saprophytic L. biflexa serovar Patoc are capable of binding fibrinogen (Fg). The interaction of leptospires with Fg inhibits thrombin- induced fibrin clot formation that may affect the haemostatic equilibrium. Additionally, we show that plasminogen (PLG)...
متن کاملCharacterization of IS1501 mutants of Leptospira interrogans serovar pomona.
Leptospira interrogans is a diverse species in which individual serovars have distinctive restriction fragment length polymorphisms that are useful in strain identification. Many of these polymorphisms can be detected using hybridization probes derived from insertion sequences; an observation that suggests these IS elements are active and can transpose in L. interrogans. Two spontaneous mutants...
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ژورنال
عنوان ژورنال: The American Journal of Tropical Medicine and Hygiene
سال: 2013
ISSN: 0002-9637,1476-1645
DOI: 10.4269/ajtmh.13-0205